Similarities: Prince of Wolf deals with a human raised by wolves who has enhanced strength and senses, and is misjudged by other people (at least initially).
Gu Family Book deals with a half human/half gumiho (fox demon) who has special powers and is treated like a monster by everyone who finds out about his true identity.
Both kinda deal with other people freaking out about their wolf/fox demon rage issues, and have a female lead who understands their true nature.
Differences: Gu Family Book is a Korean Drama, and is set in a historical setting. MC is not as "innocent"? (father of the MC is though).