Meitantei Conan (2011)

Both aired as part of the Thursday Mystery Theater programming block, and have a similar format of each episode's case being related to an aspect of the over-arcing mystery.

It's so similar: a clever and famous high school detective and a somewhat talented assistant (girl), who have feeling for each other but are shy to confess, solve mysteries

Both are famous mystery series based on two of most famous Detective manga...............................................................

both about solving mysteries in a school. both have some sort of illness that either helps or hiders them during the investigation